Surge Scientific · Model MultiEX 024L · Large Volume Nucleic Acid Extractor
Large Volume Nucleic Acid Extractor
Up to 8 mL Sample · 50 µL Elution · cfDNA & Wastewater Optimized
1–24 Samples / Run · 8 mL Max Processing Volume · 50 µL Min Elution · 160:1 Concentration Ratio · 3000 RPM Vortex Mixing · Liquid Biopsy & Environmental Surveillance
The MultiEX 024L is the specialized large-volume extractor for nucleic acid workflows that standard 200–1000 µL extractors physically cannot handle. Process up to 8 mL of starting sample per well and elute as low as 50 µL — a 160-fold concentration ratio that makes vanishingly low-abundance targets like cfDNA from liquid biopsy plasma, pathogen DNA from wastewater, and circulating tumor DNA finally detectable. Powerful oscillation mixing combines vortex action up to 3000 RPM within each well plus linear back-and-forth plate mixing — the kind of agitation 8 mL of viscous biological sample actually requires.
Why Large-Volume Extraction Is a Different Tool, Not a Bigger One
Standard nucleic acid extractors max out around 200–1000 µL of input volume per well. That works fine for whole blood DNA extraction, viral RNA from swabs, tissue homogenates — anywhere the target nucleic acid is reasonably abundant in the starting material. It does not work when your target is at femtogram-per-mL concentrations and your starting sample is biological fluid.
Cell-free DNA (cfDNA) in plasma exists at concentrations of 1–100 ng/mL — and the diagnostic signal often comes from 0.1–5% of that cfDNA being tumor-derived. To detect it, you need to start with 5–10 mL of plasma, not 200 µL. Pathogenic DNA in wastewater for environmental surveillance — SARS-CoV-2, polio, antibiotic-resistance genes — is similarly diluted and requires multi-mL starting volumes to hit detection thresholds.
The MultiEX 024L is engineered specifically for these workflows. 8 mL maximum processing volume per well across 1–24 samples per run, with elution down to 50 µL for a concentration ratio of 160:1. The mixing system — 3000 RPM vortex action within each well plus linear back-and-forth plate mixing — keeps 8 mL of viscous fluid genuinely mixed instead of stratifying. Magnetic-bead capture, washes, elution, and dispense are all automated; the only manual step is loading the prepped plate.
8 mL Max Sample Volume
Process up to 8 mL of starting sample per well — 8× the volume of a standard 1 mL extractor. The volume that liquid biopsy and environmental surveillance protocols actually need.
160:1 Concentration Ratio
8 mL in → 50 µL elution = 160-fold concentration. Detect targets at femtogram-per-mL starting concentrations that standard extraction would miss entirely.
3000 RPM In-Well Vortex
Powerful oscillation mixing — vortex up to 3000 RPM within each well plus linear back-and-forth plate motion. Keeps 8 mL of viscous biological sample genuinely mixed during binding and washes.
cfDNA · Liquid Biopsy · Wastewater
Engineered specifically for cfDNA from plasma (liquid biopsy), pathogenic DNA from wastewater and water sources, and any workflow where ultra-low-abundance nucleic acid in large starting volumes is the target.
"8 mL in. 50 µL out. The 160-to-1 concentration that makes cfDNA, wastewater pathogens, and circulating tumor DNA actually detectable." — For liquid biopsy programs, environmental surveillance, and any workflow where the target is rare and the sample is large, the MultiEX 024L is the right tool — not a bigger one.
Key Features
- Magnetic bead-based separation technology
- 1–24 samples per run
- Up to 8 mL sample processing volume
- Final elution as low as 50 µL
- 160:1 concentration ratio capability
- 96-well plate compatible
- Powerful oscillation mixing system
- Vortex mixing up to 3000 RPM within each well
- Linear back-and-forth plate mixing
- Optimized for high-viscosity samples
- Optimized for cfDNA extraction (liquid biopsy)
- Optimized for wastewater pathogen detection
- Optimized for environmental DNA (eDNA)
- Suitable for ctDNA / circulating tumor DNA
- Suitable for cell-free RNA workflows
- Touchscreen interface
- User-friendly protocol programming
- Fully automated workflow
- Open-system reagent compatibility
- High recovery from low-concentration samples
- Reproducible inter-well purification
- Suitable for research facilities
- Suitable for diagnostic laboratories
- Suitable for biotechnology industry
- Reduces hands-on time vs manual large-volume protocols
- 2-year all-inclusive warranty
Ideal Applications
Liquid Biopsy & cfDNA
Cell-free DNA extraction from 5–10 mL plasma for liquid biopsy oncology, prenatal cfDNA testing (NIPT), transplant rejection monitoring, and ctDNA / circulating tumor DNA analysis.
Wastewater Surveillance
Pathogenic DNA / RNA from wastewater and water sources — SARS-CoV-2, polio, norovirus, antibiotic-resistance gene surveillance, and public health epidemiology programs.
eDNA & Environmental Research
Environmental DNA from soil suspensions, water samples, and ecological monitoring — large starting volume captures rare-species DNA at detection-threshold concentrations.
What's in the Box
The MultiEX 024L ships ready for large-volume extraction workflows. Specialized large-volume reagent kits available — contact our specialists for cfDNA-, wastewater-, or eDNA-optimized kit recommendations.
Technical Specifications
| Parameter | Specification |
|---|---|
| Model / SKU | MultiEX 024L |
| Throughput | 1–24 samples per run |
| Maximum Sample Volume | Up to 8 mL per well |
| Minimum Elution Volume | 50 µL |
| Concentration Ratio | Up to 160:1 |
| Plate Type | 96-well plate |
| Separation Method | Magnetic bead-based |
| Reagent System | Open — compatible with magnetic-bead kits |
| In-Well Vortex Speed | Up to 3000 RPM |
| Plate Motion | Linear back-and-forth |
| Mixing System | Combined oscillation — vortex + linear |
| Display | Color touchscreen |
| Workflow Stages | Bead capture · washing · elution · dispense |
| Operation Mode | Fully automated |
| Optimized For | cfDNA · ctDNA · liquid biopsy · wastewater pathogens · eDNA |
| Intended Use | Research facilities · diagnostic laboratories · biotechnology industry |
| Warranty | 2-year all-inclusive |
Detailed numerical specifications (heating range, processing time, dimensions, weight, power) available on request — contact our product specialists for the full technical datasheet.
Surge Scientific Warranty & Support
This instrument is sold through Surge Scientific, your trusted laboratory equipment partner. Our product specialists are available Monday–Friday for assistance. The MultiEX 024L is backed by a 2-year all-inclusive manufacturer's warranty. Contact us at info@surgescientific.com or reach out directly to our support team at 855.943.3344 for pre-sales questions, cfDNA / wastewater / eDNA reagent kit recommendations, protocol optimization, validation services, and technical assistance.